Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime is active against gram-positive and gram-negative bacteria, with greater activity against both than third-generation antibiotics. Sulbactam is a β-lactamase inhibitor. It was patented in 1977. This drug is given in combination with β-lactam antibiotics. It is 16-19% Plasma protein bound. A potential alternative to BL/BLI…
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ALFAPIME-TZ (Cefepime and Tazobactam) are indicated as a parenteral therapy for the treatment of various moderate to severe forms of infections due to susceptible beta-lactamase producing microbial organisms. Cefepime and Tazobactam combination are particularly indicated if the Cefepime monotherapy is ineffective. Cefepime and Tazobactam are prescribed for the treatment of uncomplicated skin and skin structure…
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Ceftazidime is a third-generation cephalosporin antibiotic useful for the treatment of a number of bacterial infections. Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius. Used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. First line therapy for treatment of Melioidosis. It has broad coverage…
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The antibacterial component of sulbactam/cefoperazone is cefoperazone, a third-generation cephalosporin, which acts against sensitive organisms during the stage of active multiplication by inhibiting the biosynthesis of cell wall mucopeptide. Sulbactam does not possess any useful antibacterial activity, except against Neisseriaceae and Acinetobacter. However, biochemical studies with cell-free bacterial synthesis have shown it to be an irreversible inhibitor of…
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AUXITAZ is an injectable combination of two antibiotics, piperacillin and tazobactam, with broad spectrum activity against an extended range of bacterial species. Piperacillin is an extended-spectrum penicillin antibiotic, but it can be destroyed by an enzyme produced by bacteria called beta lactamase. Tazobactam inhibits beta lactamase and prevents the destruction of piperacillin. Therefore, tazobactam is given with…
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CEFITRYP-S is a combination of two antibiotic medications. Cefpirome is a fourth-generation cephalosporin with antibacterial action. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive. Sulbactam is a beta-lactamase inhibitor. It works by blocking an enzyme called beta-lactamase produced by bacteria to inactivate…
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