Ceftriaxone +Disodium Edetate + Sulbactam
Ceftriaxone + Sulbactam + Disodium Edetate (CSE) is a powerful antibiotic combination formulated to provide comprehensive treatment for severe bacterial infections, including those caused by multi-drug resistant (MDR) pathogens. This advanced formulation combines Ceftriaxone, a broad-spectrum cephalosporin, with Sulbactam, a beta-lactamase inhibitor, and Disodium Edetate, a metal ion chelator, to enhance efficacy and address the growing issue of antibiotic resistance.
COMPOSITION:
- Ceftriaxone 1g + Disodium Edetate 37 mg + Sulbactam 500mg Injection
- Ceftriaxone 2g + Disodium Edetate 74 mg + Sulbactam 1g Injection
MODE OF ACTION:
The combination of Ceftriaxone, Sulbactam, and Disodium Edetate (EDTA) works synergistically to enhance the overall effectiveness of the treatment. Ceftriaxone, a broad-spectrum cephalosporin, targets bacterial cell walls by inhibiting penicillin-binding proteins (PBPs), causing the bacteria to burst and die. Sulbactam, a beta-lactamase inhibitor, prevents bacterial enzymes from breaking down Ceftriaxone, allowing it to remain effective, especially against beta-lactamase-producing bacteria. Meanwhile, Disodium Edetate (EDTA), a metal chelator, binds to essential metal ions like calcium and magnesium, which are vital for bacterial functions. By reducing the availability of these ions, EDTA weakens bacterial processes, making it easier for Ceftriaxone to disrupt the bacterial cell wall. Together, this combination not only improves the antibiotic’s potency but also increases its ability to combat resistant bacteria, providing broader coverage and enhancing the treatment’s overall effectiveness.
INDICATIONS
- Lower Respiratory Tract Infections
- Urinary tract infections (complicated and uncomplicated)
- Bacterial Septicemia including abdominal sepsis
- Chronic suppurative otitis media
- Bones or joint infections
- Skin or soft tissue infections
- Surgical prophylaxis including post-surgical infections
- Community acquired pneumonia (CAP)
- Healthcare associated pneumonia (HCAP)
Dosage
The usual adult daily dose is 1.5 g to 3 g every 24 hours or in two divided doses, which could be increased as per severity of infection (in severe septicemic cases) to a maximum dosage of 6 g per day in divided doses.
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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