• Valniche is an antiviral medication used to treat cytomegalovirus infections
  • After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterase
  • After this, it (being an analogue of guanosine) gets incorporated into DNA and thus cannot be properly read by DNA polymerase. This results in the termination of the elongation of viral DNA
  • Valniche is used in the treatment of Cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) and prevention of CMV disease in kidney, heart, and kidney-pancreas transplant patients at high risk
  • Valniche works by slowing the growth of the CMV virus. It helps prevent the spread of infection to other areas of the body
Therapy Area: Renal Transplant
Form: Tablets
Packaging: 1X2


Valganciclovir hcl 450mg


After administration, Valganciclovir is rapidly converted to ganciclovir by hepatic and intestinal esterases. In cytomegalovirus (CMV)-infected cells, ganciclovir is initially phosphorylated to the monophosphate form by viral protein kinase, then it is further phosphorylated via cellular kinases to produce the triphosphate form. This triphosphate form is slowly metabolized intracellularly

The phosphorylation is dependent upon the viral kinase and occurs preferentially in virus-infected cells. The virustatic activity of ganciclovir is due to the inhibition of viral DNA synthesis by ganciclovir triphosphate

Ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand

Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed


  • CMV Prevention in Solid Organ Transplant
  • Cytomegalovirus Retinitis


CMV infection in Kidney transplantation

900 mg PO qDay

Begin within 10 days of transplant until 200 days post-transplant


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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