Prulitop a brand of Prucalopride is a dihydro-benzofuran-carboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties

Therapy Area: Constipation
Form: Tablet
Packaging: 1x10's


Prucalopride 1mg/2mg Tablet


Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be found throughout the gastrointestinal tract primarily in smooth muscle cells, enterochromaffin cells, and myenteric plexus. Its activation produces the release of acetylcholine which is the major excitatory neurotransmitter in the GI tract. Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content.


  • Impaired GI motility
  • Chronic Constipation


1-2 Tablets once a day


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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