Mucimega containing Acetylcysteine also known as N-acetyl cysteine comes from the amino acid L-cysteine. Amino acids are the building blocks of proteins. Acetylcysteine has many uses as medicine. It is a medication that is used to treat paracetamol (acetaminophen) overdose, and to loosen thick mucus in individuals with cystic fibrosis or chronic obstructive pulmonary disease. It is used for mucus dissolving, mucolytic therapy in addition to other therapies in respiratory conditions with excessive thick mucus production. It is also used post-operatively, as a diagnostic aid, and in tracheotomy care. Acetylcysteine is considered to be ineffective in cystic fibrosis. It’s essential for immune health and fighting cellular damage. Acetylcysteine is needed to make and replenish glutathione.
MODE OF ACTION:
Acetylcysteine protects against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. It does this by producing the glutathione precursor L-cysteine. Glutathione is required to inactivate an intermediate metabolite of acetaminophen that is thought to be hepatotoxic. Acetylcysteine acts by reducing the metabolite to the parent compound and/or by providing sulfhydryl for conjugation of the metabolite. The mechanisms of action for acetylcysteine’s well-known mucolytic effects are different. In particular, when inhaled, acetylcysteine (and its metabolic byproduct cysteine) exerts its mucolytic action through its free sulfhydryl group, which reduces the disulfide bonds in the mucus matrix and lowers mucus viscosity. This action increases with increasing pH and is most significant at pH 7 to 9. The mucolytic action of acetylcysteine is not affected by the presence of DNA. Acetylcysteine is also an antioxidant and reduces oxidative stress.
- Acute & chronic bronchitis
- Paracetamol poisoning
- Prevention of contrast induced nephropathy
- Idiopathic pulmonary fibrosis
- Neurological disorders
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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