Minocycline
Milifast contains Minocycline Hydrochloride, a second-generation semi-synthetic tetracycline antibiotic. Approved by the FDA on June 30, 1971, Minocycline is effective against a wide range of gram-positive and gram-negative bacteria. It is recognized for its longer half-life and high serum concentration, providing a more sustained effect compared to earlier tetracyclines. Minocycline has proven to be highly effective in treating Acinetobacter infections and is also FDA-approved for the treatment of sexually transmitted diseases (STDs) and rheumatoid arthritis. With excellent tissue penetration and a better pharmacokinetic profile than first-generation tetracyclines, it ensures rapid and complete absorption, even in elderly populations.
In addition to its antibiotic properties, Minocycline has a bacteriostatic effect, meaning it inhibits bacterial growth rather than directly killing bacteria. Its unique lipophilic nature allows it to penetrate tissues effectively, making it suitable for treating a variety of infections. It binds to 76% of proteins in the bloodstream, ensuring prolonged action and effective treatment, particularly for conditions resistant to other antibiotics. Minocycline’s broad-spectrum activity and high tissue penetration make it an essential option in treating several bacterial infections, including respiratory infections, acne, and skin conditions.
COMPOSITION:
- Minocycline 100mg Injection
- Minocycline Hydrochloride 100mg Tablet
MODE OF ACTION:
Minocycline works by inhibiting protein synthesis in bacteria. It enters bacterial cells through porins, where it coordinates with cations like magnesium to cross the bacterial outer membrane. Once inside the periplasm, the lipophilic Minocycline dissociates, diffusing into the bacterial cytoplasm. There, it prevents the binding of aminoacyl-tRNA to the 30S ribosomal subunit, inhibiting protein synthesis. By disrupting this vital step, Minocycline stops bacterial growth and replication, making it a bacteriostatic agent.
Unlike many other antibiotics, Minocycline has a longer half-life and better pharmacokinetics compared to earlier tetracyclines. This allows for high serum concentrations and excellent tissue penetration, enhancing its efficacy, even against resistant bacterial strains. Minocycline’s ability to achieve high levels in tissues helps in the treatment of various infections, and its lipophilic nature ensures it is absorbed efficiently in the body, even in elderly patients.
INDICATIONS
- Acute Ischemic stroke
- Meningitis
- Prophylaxis of asymptomatic meningitis
- Venereal diseases
- RTI
- UTI
- SSSI
- Syphilis
Dosage
Adults:
- 200 mg IV initially, then 100 mg IV every 12 hours (Max: 400 mg/24 hrs).
- 200 mg orally daily in divided doses.
Children (above 8 years):
- 4 mg/kg IV initially, then 2 mg/kg IV every 12 hours.
- 50 mg orally every 12 hours.
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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