Meropenem & Sulbactum
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. It is used as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms such as Staphylococcus aureus, Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci and Enterococcus faecali. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.
Sulbactam is a β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys antibiotic activity.
COMPOSITION:
Meropenem 1gm/ Salbactun 500 mg
MODE OF ACTION:
The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus .
Sulbactam is an irreversible inhibitor of β-lactamase; by binding and inhibiting β-lactamase produced by bacterial cells, sulbactam is thereby able to prevent it from reducing antibiotic activity. aureus.
INDICATIONS
- Sepsis
- Bacterial Meningitis
- Skin and Skin Structure Infections
- Hospital-acquired pneumonia (HAP)
- Complicated intraabdominal infections (CAI)
Dosage
Adults: 500mg-2gm depending on the severity and dosage should be continued every 8 hours
Pediatric: 10-40 mg/kg depending on the severity and dosage should be continued every 8 hours.
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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