Levetiracetam
Levialfa (Levetiracetam) is a drug within the pyrrolidine class that is used to treat various types of seizures originates from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs). It possesses a wide therapeutic index and little-to-no potential to produce, or be subject to, pharmacokinetic interactions. These characteristics make it a desirable choice over other AEDs.
Levetiracetam is a relatively unique anticonvulsant that is typically used alone or in combination with other antiepileptic medications.
Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
COMPOSITION:
Levetiracetam 250/500 Tablet
Levetiracetam 500mg/5ml Injection
MODE OF ACTION:
Levetiracetam has a novel mode of action, it binds to synaptic vesicle glycoprotein 2A (SV2A). SV2A is a membrane-bound protein that is found on synaptic vesicles and is present everywhere throughout the CNS. It appears to play a role in vesicle exocytosis and in the modulation of synaptic transmission by increasing the available amount of secretory vesicles available for neurotransmission. Stimulation of pre-synaptic SV2A by levetiracetam may inhibit neurotransmitter release, but this action does not appear to affect normal neurotransmission. Levetiracetam has also been shown to indirectly affect GABAergic neurotransmission (despite having no direct effect on GABAergic or glutamatergic receptors) and modulate ionic currents. Similarly, levetiracetam has been shown in vitro to inhibit N-type calcium channels.
INDICATIONS
- Partial Seizures
- Myoclonic Seizures
- Generalized Tonic-Clonic Seizures
- Refractory Epilepsy
Dosage
Dosage– Recommended Adult Dosage:
Tablet:
Initial dose – 1000mg/day in divided doses (500 mg BID)
Incremental Dose – 1000mg/day every week
Maximum dose- 3000 mg/day
Injection:
In Partial Onset Seizures & Myoclonic Seizures-
500 mg twice daily, increase by 500 mg twice daily every 2 weeks to the recommended dose of
1500 mg twice daily
In Seizure Prophylaxis – 3000 mg/day for the first 2 days, followed by 2000 mg/day for the next 2 days, and then 1000 mg/day
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
Enquire About Levialfa
Fill the form below and we will get in touch with you