Midodrine Hydrochloride
An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of orthostatic hypotension. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies.
COMPOSITION:
Midodrine Hydrochloride 2.5mg Tablets
MODE OF ACTION:
Midodrine undergoes metabolism to form its pharmacologically active metabolite, desglymidodrine. Desglymidodrine acts as an agonist at the alpha1-adrenergic receptors expressed in the arteriolar and venous vasculature. Activation of alpha1-adrenergic receptor signaling pathways leads to an increase in the vascular tone and elevation of blood pressure. Desglymidodrine is reported to have a negligible effect on the cardiac beta-adrenergic receptors
INDICATIONS
- Symptomatic orthostatic hypotension
- Hepatorenal syndrome
- Ascites
Dosage
Maintenance Dose – May be increased weekly up to a dose of 10 mg three times a day (depending on the results of supine and standing blood pressure recordings.
Caution – Should not be given after the evening meal or less than 4 hours before bedtime (to reduce the potential for supine hypertension during sleep
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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