Hypodrin contains Midodrine Hydrochloride which is used in the ascites. Ascites is the most common complication of liver cirrhosis. Midodrine is a vasoconstrictor that improves splanchnic and systemic hemodynamics, reduces ascites. An ethanolamine derivative that is an adrenergic alpha agonist. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies.
Hypodrin has two SKUs Hypodrin 2.5mg and Hypodrin 5 mg
Midodrine Hydrochloride 2.5mg
Midodrine Hydrochloride 5mg
MODE OF ACTION:
Midodrine has been found to decrease nitrite and nitrate activity in patients with ascites (Nitrate reduces blood pressure) and who had decreased plasma renin activity and decreased levels of antidiuretic hormone (retain water and salt in body).
Midodrine undergoes metabolism to form its pharmacologically active metabolite, desglymidodrine. Desglymidodrine acts as an agonist at the alpha1-adrenergic receptors expressed in the arteriolar and venous vasculature. Activation of alpha1-adrenergic receptor signaling pathways leads to an increase in the vascular tone and elevation of blood pressure. Desglymidodrine is reported to have a negligible effect on the cardiac beta-adrenergic receptors
- Symptomatic orthostatic hypotension
- Hepatorenal syndrome
Midodrine Hydrochloride 2.5mg: Three times daily
Midodrine Hydrochloride 5 mg: Three times daily and adjusting the dose (by increments of 2.5 mg for each dose, as needed) every 24 h (maximal dose 17.5 mg three times daily)
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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