Midodrine Hydrochloride

An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of orthostatic hypotension. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies.

Therapy Area: Vasopressin & Analogues
Form: Tablet
Packaging: 1x10 tablets

COMPOSITION:

Midodrine Hydrochloride 2.5mg Tablets

MODE OF ACTION:

Midodrine undergoes metabolism to form its pharmacologically active metabolite, desglymidodrine. Desglymidodrine acts as an agonist at the alpha1-adrenergic receptors expressed in the arteriolar and venous vasculature. Activation of alpha1-adrenergic receptor signaling pathways leads to an increase in the vascular tone and elevation of blood pressure. Desglymidodrine is reported to have a negligible effect on the cardiac beta-adrenergic receptors

INDICATIONS

  • Symptomatic orthostatic hypotension
  • Hepatorenal syndrome
  • Ascites

Dosage

Maintenance Dose – May be increased weekly up to a dose of 10 mg three times a day (depending on the results of supine and standing blood pressure recordings.

Caution – Should not be given after the evening meal or less than 4 hours before bedtime (to reduce the potential for supine hypertension during sleep

Disclaimer:

This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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