Midodrine Hydrochloride

An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of orthostatic hypotension. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies.

Therapy Area: Vasopressin & Analogues
Form: Tablet
Packaging: 1x10 tablets


Midodrine Hydrochloride 2.5mg Tablets


Midodrine undergoes metabolism to form its pharmacologically active metabolite, desglymidodrine. Desglymidodrine acts as an agonist at the alpha1-adrenergic receptors expressed in the arteriolar and venous vasculature. Activation of alpha1-adrenergic receptor signaling pathways leads to an increase in the vascular tone and elevation of blood pressure. Desglymidodrine is reported to have a negligible effect on the cardiac beta-adrenergic receptors


  • Symptomatic orthostatic hypotension
  • Hepatorenal syndrome
  • Ascites


Maintenance Dose – May be increased weekly up to a dose of 10 mg three times a day (depending on the results of supine and standing blood pressure recordings.

Caution – Should not be given after the evening meal or less than 4 hours before bedtime (to reduce the potential for supine hypertension during sleep


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

Enquire About HYPODRIN

Fill the form below and we will get in touch with you

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.