Pregabalin + Nortriptyline

Pregabalin has approval from the United States Food and Drug Administration (FDA) for the treatment of neuropathic pain associated with diabetic peripheral neuropathy, spinal cord injury, and postherpetic neuralgia. Pregabalin is FDA-approved for the treatment of fibromyalgia. Pregabalin is also FDA approved as adjunctive therapy for partial-onset seizures in adults with epilepsy. Off-label uses include generalized anxiety disorder, social anxiety disorder, bipolar disorder, insomnia, and chronic pain conditions not otherwise approved by the FDA.

Nortriptyline is an antidepressant that falls under the pharmacological category of tricyclics (secondary amine), more commonly known as TCAs.

Therapy Area: Neuropathic Pain, Mental illness.
Form: Tablet
Packaging: 10x10Tablet


Pregabalin 75mg  + Nortriptyline 10mg Tablet


Pregabalin binds to presynaptic voltage-gated calcium channels at the alpha-2-delta subunit in central nervous system tissues. Binding of the alpha-2-delta subunit decreases the depolarization-induced influx of calcium into neurons and thus reduces the release of excitatory neurotransmitters. This action may account for the anticonvulsant and analgesic effects of pregabalin.

Nortriptyline inhibits the reuptake of serotonin and norepinephrine by the presynaptic neuronal membrane, thereby increasing the concentration of those neurotransmitters in the synapse. Additionally, nortriptyline inhibits the activity of histamine, 5-hydroxytryptamine, and acetylcholine.


  • Diabetic Neuropathy
  • Post – Herpetic Neuralgia
  • Fibromyalgia
  • Anxiety disorders
  • Ortho – Neuronal Disorders


1 Tablets in a day.


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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