Gabapentin + Nortriptyline

Gabapentin is a synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant activity. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) that was first approved for use in the United States in 1993.It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures1 today it is also widely used to treat neuropathic pain

Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA) and from the same class of medicines as amitriptyline, which is widely recommended for treating neuropathic pain; nortriptyline may also be useful in these painful conditions.

Therapy Area: Neurodegenerative, Neurodevelopment & Mental Health
Form: Tablet
Packaging: 1x10 Tablet


Gabapentin 400mg + Nortriptyline 10mg Tablet


Gabapentin works by showing a high affinity for binding sites throughout the brain correspondent to the presence of the voltage-gated calcium channels, especially alpha-2-delta-1, which seems to inhibit the release of excitatory neurotransmitters in the presynaptic area which participate in epileptogenesis. Even though there is no evidence for direct action at the serotonin, dopamine, benzodiazepine, or histamine receptors, research has shown gabapentin to increase total-blood levels of serotonin in healthy control subjects.


Nortriptyline inhibits the reuptake of serotonin and norepinephrine by the presynaptic neuronal membrane, thereby increasing the concentration of those neurotransmitters in the synapse also inhibits the activity of histamine, 5-hydroxytryptamine, and acetylcholine


  • Diabetic Neuropathy
  • Post – Herpetic Neuralgia
  • Fibromyalgia
  • Anxiety Disorders
  • Ortho – Neuronal Disorders


One Tablet in a day.


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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