Esomeprazole, Domperidone, Levosulpiride, Itopride
ESOBIZ (Esomeprazole): A proton pump inhibitor indicated for acid suppression. It is utilized in cases of erosive esophagitis, Peptic Ulcer Disease (PUD), and Gastroesophageal Reflux Disease (GERD) where gastric acid control is the primary therapeutic requirement.
ESOBIZ-DSR (Esomeprazole + Domperidone): A combination formulation of a PPI and a peripheral dopamine D2 receptor antagonist. It is indicated for acid-related disorders accompanied by symptoms such as nausea, vomiting, or regurgitation.
ESOBIZ-L (Esomeprazole + Levosulpiride): A combination formulation of a PPI and a selective dopamine D2 receptor antagonist. It is utilized in cases of functional dyspepsia and acid-related disorders presenting with abdominal bloating or dysmotility.
ESOBIZ-IT (Esomeprazole + Itopride): A combination formulation of a PPI and a dual-action prokinetic (dopamine D2 antagonist and acetylcholinesterase inhibitor). It is utilized for symptoms of functional dyspepsia, including post-prandial distress, early satiety, and epigastric heaviness.
COMPOSITION:
| ESOBIZ | Esomeprazole 40 mg Tablet |
| ESOBIZ-DSR | Esomeprazole 40 mg + Domperidone 30 mg Capsule |
| ESOBIZ-L | Esomeprazole 40 mg + Levosulpiride 75 mg Capsule |
| ESOBIZ-IT | Esomeprazole 40 mg + Itopride 150 mg Capsule |
MODE OF ACTION:
Esomeprazole: A gold-standard PPI that irreversibly inhibits the H+/K+ ATPase pump in gastric parietal cells. It effectively suppresses both basal and stimulated acid secretion, ensuring superior healing of gastric and duodenal ulcers.
Domperidone: A peripheral dopamine D2 antagonist. It accelerates gastric emptying and exerts potent antiemetic effects by acting on the chemoreceptor trigger zone, making it ideal for GERD associated with nausea and regurgitation.
Levosulpiride: A selective dopamine D2 antagonist that enhances acetylcholine release in the myenteric plexus. It significantly improves gastrointestinal motility and increases lower esophageal sphincter (LES) tone, providing relief in functional dyspepsia and bloating.
Itopride: A dual-action prokinetic that acts as a dopamine D2 antagonist and an acetylcholinesterase inhibitor. By preventing acetylcholine breakdown, it boosts gastric transit and effectively resolves post-meal fullness, early satiety, and heaviness.
INDICATIONS
- Hyperacidity
- Heartburn
- Gastroesophageal reflux disease
- Peptic ulcer
- Functional dyspepsia
- Gastroparesis / delayed gastric emptying
- Bloating and indigestion
- Nausea and vomiting
- NSAID-induced gastric ulceration
Dosage
1 tablet/capsule once daily before meals or as directed by physician
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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