Escitalopram Oxalate

Escipix (Escitalopram) is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic citalopram. It is used to restore serotonergic function in the treatment of depression and anxiety. Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible for the vast majority of citalopram’s clinical activity, with some evidence suggesting that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer. Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects as compared to other agents in this class. Escitalopram also differentiates itself from other SSRIs via allosteric action on its target – this may be the mechanism responsible for its observed superior efficacy and faster onset compared to other SSRIs.

Therapy Area: Antidepressant and Anxiolytic
Form: Tablet
Packaging: 1x10 Tablets


Escitalopram Oxalate 5/10mg Tablet


Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors.

Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding. Its combination of orthosteric and allosteric activity on SERT allows for greater extracellular 5-HT levels, a faster onset of action, and greater efficacy as compared to other SSRIs. Escitalopram has shown little-to-no binding affinity at a number of other receptors, such as histamine and muscarinic receptors, and minor activity at these off-targets may explain some of its adverse effects.


  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Obsessive Compulsive Disorder (OCD)
  • Panic Disorder with or without Agoraphobia


Recommended Dosage

Adult Dosage for (MDD) & (GAD)

Initial dose: 10mg/day; may increase to 20mg/day after 1 week

Maintenance dose: 10 to 20mg/day

Maximum dose: 20mg/day

Adult Dosage for OCD

20 to 40mg/day


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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