DULAFIX (anidulafungin) is a sterile, lyophilized intravenous (IV) infusion.
Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibit the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin (Vicuron Pharmaceuticals) is a new echinocandin antifungal with potent activity against Aspergillus and Candida spp. Anidulafungin is a noncompetitive inhibitor of (1,3)-β-D-glucan synthase within fungal cells
Broad spectrum antifungal with potent activity against Aspergillus & Candida. The drug is rapidly distributed and steady-state concentrations are achieved after the first dose, when a loading dose of twice the daily maintenance dose is given on day 1. Drug biotransformation occurs via chemical degradation, with no hepatic metabolism or renal elimination
Anidulafungin 100 mg
MODE OF ACTION:
Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibitsglucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3-β-D-glucan, an essential component of the fungal cell wall.
Anidulafungin selectively inhibits 1,3-β-D glucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3--D-glucan, an essential component of the fungal cell wall. Anidulafungin has shown fungicidal activity against Candida species and activity against regions of active cell growth of the hyphae of Aspergillus fumigatus.
- Candidal Peitonitis
- Intra Abdominal Abscess
- Esophageal Candidiasis
Candidemia, Candidal Peritonitis, Intra Abdominal Abscess:
Day 1 – 200 mg through IV infusion therapy
Day 2 – 100 mg/day IV generally continue up to 14 days after last positive culture report
Esophageal Candidiasis:Day 1 – 100 mg through IV infusion
Day 2 – 50 mg/day IV at least up to 14 days of treatment
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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