Anidulafungin
DULAFIX (anidulafungin) is a sterile, lyophilized intravenous (IV) infusion.
Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of Aspergillus nidulans. Anidulafungin is an echinocandin, a class of antifungal drugs that inhibit the synthesis of 1,3-β-D-glucan, an essential component of fungal cell walls. Anidulafungin (Vicuron Pharmaceuticals) is a new echinocandin antifungal with potent activity against Aspergillus and Candida spp. Anidulafungin is a noncompetitive inhibitor of (1,3)-β-D-glucan synthase within fungal cells
Broad spectrum antifungal with potent activity against Aspergillus & Candida. The drug is rapidly distributed and steady-state concentrations are achieved after the first dose, when a loading dose of twice the daily maintenance dose is given on day 1. Drug biotransformation occurs via chemical degradation, with no hepatic metabolism or renal elimination
COMPOSITION:
Anidulafungin 100 mg
MODE OF ACTION:
Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibitsglucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3-β-D-glucan, an essential component of the fungal cell wall.
Anidulafungin selectively inhibits 1,3-β-D glucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3--D-glucan, an essential component of the fungal cell wall. Anidulafungin has shown fungicidal activity against Candida species and activity against regions of active cell growth of the hyphae of Aspergillus fumigatus.
INDICATIONS
- Candidemia
- Candidal Peitonitis
- Intra Abdominal Abscess
- Esophageal Candidiasis
Dosage
Candidemia, Candidal Peritonitis, Intra Abdominal Abscess:
Day 1 – 200 mg through IV infusion therapy
Day 2 – 100 mg/day IV generally continue up to 14 days after last positive culture report
Esophageal Candidiasis:Day 1 – 100 mg through IV infusion
Day 2 – 50 mg/day IV at least up to 14 days of treatment
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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