Tacrolimus is an immunosuppressive drug. It is also used in a topical preparation in the treatment of severe atopic dermatitis and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription.
Tacrolimus 0.03% w/w/Tacrolimus 0.1% w/w
MODE OF ACTION:
- Lichen planus
Apply once daily preferably at night
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.