Auxitrol (calcitriol) is considered to be the most potent metabolite of vitamin D in humans. Renal production of calcitriol is stimulated in response to PTH, low calcium and low phosphate. Calcitriol plays a role in plasma calcium regulation in concert with parathyroid hormone (PTH) by enhancing absorption of dietary calcium and phosphate from the gastrointestinal tract, promoting renal tubular reabsorption of calcium in the kidneys, and stimulating the release of calcium stores from the skeletal system. In addition to promoting fatty acid synthesis and inhibiting lipolysis, calcitriol has been demonstrated to increase energy efficiency by suppressing UCP2 expression, which is modulated by signaling pathways of classical nuclear receptors (nVDR), where calcitriol acts as a natural ligand. AUXITROL effectively decreases PTH levels, decreases bone resorption, improves endosteal fibrosis and mineralization, and to some extent helps in the bone pains associated with renal osteodystrophy
Calcitriol 0.25mcg Softgel Capsule
MODE OF ACTION:
Calcitriol acts on cells in the gastrointestinal tract to increase the production of calcium transport proteins, termed calbindin-D proteins, which results in increased uptake of calcium from the gut into the body. Calcitriol has a direct inhibiting effect on PTH synthesis. It inhibits parathyroid gland activity by decreasing parathyroid hormone synthesis and release.
Calcitriol increases blood calcium levels ([Ca2+]) by:
- Promoting absorption of dietary calcium from the gastrointestinal tract.
- Increasing renal tubular reabsorption of calcium, thus reducing the loss of calcium in the urine.
- Stimulating release of calcium from bone. For this it acts on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL (Receptor activator of nuclear factor kappa-Β ligand), which in turn activates osteoclasts.
- Renal osteodystrophy
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.