Topiramate
Ultramate (Topiramate) is an anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.
Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel anti-diabetic drug. Topiramate is most soluble in alkaline solutions containing sodium hydroxide or sodium phosphate and having a pH of 9 to 10.
COMPOSITION:
Topiramate 50/100mg Tablet
MODE OF ACTION:
The exact mechanisms by which topiramate exerts pharmacological actions on seizures and migraines are currently not fully characterized. Several properties of this drug, however, are likely to contribute to its therapeutic effects. Topiramate has been observed to exert actions on voltage-dependent sodium channels, GABA receptors, and glutamate receptors.
Topiramate stimulates GABA-A receptor activity at brain non-benzodiazepine receptor sites and reduces glutamate activity at both AMPA and kainate receptors. Normally, GABA-A receptors are inhibitory and glutaminergic receptors are stimulatory for neuronal activity. By increasing GABA activity and inhibiting glutamate activity, topiramate blocks neuronal excitability, preventing seizures and migraines. Additionally, it blocks the voltage-dependent sodium channels, further blocking seizure activity. Topiramate has been shown to inhibit various carbonic anhydrase isozymes, but the clinical significance of this is unknown at this time.
INDICATIONS
- Migraine Prophylaxis
- Partial Seizure
- Tonic-Clonic Seizure
- Lennox-Gastaut Syndrome
Dosage
Recommended Adult Dosage
Migraine Prophylaxis
Initial Dose: 25 to 50mg a day
Maintenance Dose: 50 to 100mg daily in divided doses
Maximum Dose: 200mg daily
Epilepsy
Initial Dose: 50mg for 1 Week
Maintenance Dose: 100 to 200mg daily in 2 divided doses
Maximum Dose: 500mg daily
Lennox-Gastaut Syndrome
Initial Dose: 0.5-1mg/kg at night for 1 Week,
Increased by 0.5-1mg/kg at 1-2 Week interval
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
Enquire About Ultramate
Fill the form below and we will get in touch with you