THIAMINE

Thiamine hydrochloride injection), IP is a sterile solution of thiamine hydrochloride in water for Injection for intramuscular (IM) or intravenous (IV) administration. Thiamine water-soluble vitamin; found in yeast, cereal grains, legumes, peas, nuts, pork, and beef.

Thiamine hydrochloride, or vitamin B1, occurs as white crystals or crystalline powder that usually have a slight characteristic odor. Freely soluble in water; soluble in glycerin; slightly soluble in alcohol; insoluble in ether and benzene. Thiamine is rapidly destroyed in neutral or alkaline solutions but is stable in the dry state. It is reasonably stable to heat in acid solution. The chemical name of thiamine hydrochloride is thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-5-(2-hydroxyethyl)-4-methylchloride, monohydrochloride.

Therapy Area: Nutrition
Form: Injection
Packaging: 5X2ml Ampoule

COMPOSITION:

Thiamine Hcl 100mg

MODE OF ACTION:

Thiamine combines with adenosine triphosphate (ATP) in the liver, kidneys, and leukocytes to produce thiamine pyrophosphate. Thiamine pyrophosphate acts as a coenzyme in carbohydrate metabolism, in transketolation reactions, and in the utilization of hexose in the hexose-monophosphate shunt. Without adequate thiamine, pyruvic acid does not undergo conversion to acetyl-CoA and cannot enter the Krebs cycle. Pyruvic acid accumulates in the blood and is subsequently converted to lactic acid, with the potential development of lactic acidosis. Diminished production of NADH in the Krebs cycle also results in lactic acid production through facilitation of anaerobic glycolysis.

INDICATIONS

  • Beriberi (wet & dry beriberi)
  • Wernicke's/ Korsakoff syndrome
  • Alcoholic Dementia
  • Polyneuritis

Dosage

Mild thiamine deficiency – the usual dose for adults is between 25mg and 100mg, taken once a day.

Severe thiamine deficiency – the usual dose for adults is 100mg, taken 2 or 3 times a day

Disclaimer:

This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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