Terlijet (Terlipressin) is a medicine similar to a naturally occurring hormone present in the body, known as antidiuretic hormone (ADH) or vasopressin. ADH has two main effects in the body. Firstly, it causes narrowing of blood vessels (vasoconstriction), thereby limiting blood flow to a particular area of the body. It also acts on receptors in the kidney to retain water in the body, which helps to prevent excessive loss of water in the urine.
Terlijet Injection is used in the treatment of bleeding esophageal varices (bleeding from dilated veins in the food pipe leading to your stomach). It narrows the walls of blood vessels and decreases the blood flow into the affected veins.
MODE OF ACTION:
Terlipressin, an analogue of vasopressin, acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotropin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medulla. The binding of terlipressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullary duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.
- Acute esophageal variceal hemorrhage
- Gastro-intestinal hemorrhage
- Uro-genital hemorrhage
- Cirrhotic hepto-renal syndrome
- Septic shock
2mg IV stat, followed by 1mg every 4-6hrs for 24-72hrs
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.