Piperacillin Sodium + Tazobactum Sodium
TAZONICHE is a combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam. The combination has activity against many Gram-positive and Gram negative bacteria including Pseudomonas aeruginosa. Piperacillin and Tazobactam injection is used to treat pneumonia and skin, gynecological, and abdominal (stomach area) infections caused by bacteria. Piperacillin is in a class of medications called penicillin antibiotics. It works by killing bacteria that cause infection. Tazobactam is in a class called beta-lactamase inhibitor. It works by preventing bacteria from destroying piperacillin.
Piperacillin Sodium 2gm + Tazobactum Sodium 250mg / Piperacillin Sodium 4gm + Tazobactum Sodium 500mg
MODE OF ACTION:
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor.
Tazobactam broadens the spectrum of piperacillin by making them effective against organisms that express beta-lactamase and would normally degrade them. This occurs through the irreversible inhibition of beta-lactamase enzymes.
- Ventilator-associated pneumonia(VAP)
- Hospital-acquired pneumonia (HAP)
- Community Acquired Pneumonia (CAP)
- Skin and Skin Structure Infections
- Complicated intraabdominal infections (CIAI)
- Neutropenic Fever
- Septic shock
4.5 gm IV 6-8 hour; not to exceed 18g /day
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.