Rabeprazole, Domperidone, Levosulpride
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug – in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Levosulpiride is an enantiomer of sulpiride that exhibits anti-emetic, anti-dyspeptic, anti-psychotic and anti-depressant activities. Levosulpiride specifically blocks dopamine D2 receptors in the central nervous system (CNS) and gastrointestinal (GI) tract.
COMPOSITION:
Rabeprazole 20 mg Tab
Rabeprazole 20 mg + Domperidone 30mg Cap.
Rabeprazole 20 mg + Levosulpride 75mg Tab.
MODE OF ACTION:
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach.
Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a dopamine receptor antagonist and 2) as a serotonin 5HT receptor agonist, conferring this drug with a cholinergic effect. At a dosage of 25mg three times daily, levosulpiride accelerates gastric and gallbladder emptying.
INDICATIONS
- Hyperacidity
- Peptic ulcer
- Gastroparesis
- GERD
- Dyspepsia
- NSAIDs induced ulcer
Dosage
1 Tablet/Capsule once a day
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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