Divalproex Sodium

Nudival (Divalproex Sodium) is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. Valproic acid is clear, colorless to pale yellow, slightly viscous liquid, and sparingly soluble in water, whereas sodium valproate is a white crystalline, hygroscopic, and highly soluble in water and alcohol. Divalproex sodium is fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache. It has a role as an antimanic drug, an anticonvulsant and a GABA agent.

Therapy Area: Antimigraine / Mood Stabilizer
Form: Prolonged Release Tablet
Packaging: 1x10Tablets


Divalproex Sodium 250/500/1000mg Prolonged Release Tablet


The exact mechanisms by which divalproex sodium exerts its effects on epilepsy, migraine headaches, and bipolar disorder are unknown however several pathways exist which may contribute to the drug’s action.


Valproate is known to inhibit succinic semialdehyde dehydrogenase. This inhibition results in an increase in succinic semialdehyde which acts as an inhibitor of GABA transaminase ultimately reducing GABA metabolism and increasing GABAergic neurotransmission. As GABA is an inhibitory neurotransmitter, this increase results in increased inhibitory activity. A possible secondary contributor to cortical inhibition is a direct suppression of voltage gated sodium channel activity and indirect suppression through effects on GABA.


  • Migraine Prophylaxis
  • Bipolar Disorder (Manic Episodes)
  • Epilepsy


Recommended Adult Dosage

Migraine Prophylaxis

Initial Dose: 250mg twice a day for 1 week

Optimal Dose: 750 to 1500mg/day


Bipolar Disorder (Manic Episodes)

Initial Dose: 25 mg/kg orally once daily

Optimal Dose: Not to exceed 60 mg/kg/day



Initial Dose: 10-15mg/kg/day

Maintenance Dose: Increase by 5-10mg/kg/day every week


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

Enquire About Nudival

Fill the form below and we will get in touch with you

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.