Itraconazole is an imidazole/triazole type antifungal agent. Itraconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase. This enzyme converts lanosterol to ergosterol, and is required in fungal cell wall synthesis. The subsequent loss of normal sterols correlates with the accumulation of 14 α-methyl sterols in fungi and may be partly responsible for the fungistatic activity of fluconazole.
Itraconazole 100 mg capsule/Itraconazole 200 mg capsule /Itraconazole 1% w/w Absorbent Dusting powder
MODE OF ACTION:
Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride / phospholipid biosynthesis.
- Tinea Pedis
- Tinea Corporis
- Tinea Versicolor
200 mg twice a day for onychomycosis
100-200 mg per day for Tinea pedis/Tinea corporis
200 mg per day for Tinea versicolor
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.