Donepezil HCl + Memantine HCL

Donibiz (Donepezil) is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have Alzheimer’s disease. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer’s Disease, and in some cases, is used to manage other types of dementia. Donepezil was first approved by the FDA in 1996, and was approved in combination with Memantine in 2014 to manage moderate and severe forms of Alzheimer’s dementia.

Therapy Area: Alzheimer
Form: Tablet
Packaging: 10x10 Tablet


Donepezil HCl 5mg + Memantine HCL 5mg/10mg


Donepezil selectively and reversibly inhibits the acetylcholinesterase enzyme, which normally breaks down acetylcholine. The main pharmacological actions of this drug are believed to occur as the result of this enzyme inhibition, enhancing cholinergic transmission, which relieves the symptoms of Alzheimer’s dementia. In addition to the above, other mechanisms of action of donepezil are possible, including the opposition of glutamate-induced excitatory transmission via downregulation of NMDA receptors and the regulation of amyloid proteins, which have demonstrated significant effects on the disease process of Alzheimer’s.

Memantine blocks the NMDA-receptor subtype of glutamate receptors preventing over-activation of glutamine receptors while allowing the normal activity. Its blocking effects antagonize an overactive glutaminergic system in the central nervous system (CNS) which is thought to be involved in the neurotoxicity seen in Alzheimer disease


  • Dementia Associated to Alzheimer’s Diseases


1 or 2 Tablet in a day


This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.

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