Flucytosine
CYTOBUZ (flucytosine), also known as 5-fluorocytosine, is an antifungal medication. It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis. It may be used by itself or with other antifungals for chromomycosis.
COMPOSITION:
Flucytosine 500 mg
MODE OF ACTION:
Flucytosine is taken up by fungal organisms via the enzyme cytosine permease. Inside the fungal cell, flucytosine is rapidly converted to fluorouracil by the enzyme cytosine deaminase. Fluorouracil exerts its antifungal activity through the subsequent conversion into several active metabolites, which inhibit protein synthesis by being falsely incorporated into fungal RNA or interfere with the biosynthesis of fungal DNA through the inhibition of the enzyme thymidylate synthetase.
INDICATIONS
- Septicaemia
- Meningitis
- Endocarditis
- Pulmonary infection
- UTI
- Septicemia
Dosage
The usual dosage of CYTOBUZ is 50 to 150 mg/kg/day administered in divided doses at 6-hour intervals.
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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