Oxiconazole Nitrate
Oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and inhibits fungal cell growth. For superficial fungal infection, it is proven and well tolerated Anti-fungal. Auxicreme is highly effective against many dermatophytes, significant decline in the symptom scores of erythema, pruritus,scaling & burning in patients. Auxicreme shows high potency at lower doses.
COMPOSITION:
Oxiconazole Nitrate 1%
MODE OF ACTION:
Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.
INDICATIONS
- Tinea pedis
- Athlete foot
- Tinea cruris
- Tinea corporis
Dosage
Twice daily
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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