Cefepime + Sulbactam
Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994.
Cefepime is active against gram-positive and gram-negative bacteria, with greater activity against both than third-generation antibiotics.
Sulbactam is a β-lactamase inhibitor. It was patented in 1977. This drug is given in combination with β-lactam antibiotics. It is 16-19% Plasma protein bound. A potential alternative to BL/BLI combination. Effective in Severe Multidrug-resistant infection & active against ESBLs producing bacteria (Beta-lactamase/Beta-Lactamase Inhibitor)
Cefepime 1g + Sulbactum 500 mg
MODE OF ACTION:
Cefepime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. Sulbactam is an irreversible ß-lactamase inhibitor that binds the ß-lactamase enzyme and does not allow it to interact with the antibiotic, thus extending its spectrum of activity.
Sulbactam not only potentiates the antibacterial activity by inhibiting beta-lactamases but also forms a protein complex with beta-lactamases. Thus, sulbactam addition extends the spectrum of activity of cefepime.
- Gynecological Infections
- Complicated and Uncomplicated UTI Infections
- Empiric Treatment for fibril neutropenic patient
Twice or thrice a day in equally divided dosage depending upon disease severity. Maximum daily dose up to 9gm
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.