Cefepime + Sulbactam
Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994.
Cefepime is active against gram-positive and gram-negative bacteria, with greater activity against both than third-generation antibiotics.
Sulbactam is a β-lactamase inhibitor. It was patented in 1977. This drug is given in combination with β-lactam antibiotics. It is 16-19% Plasma protein bound. A potential alternative to BL/BLI combination. Effective in Severe Multidrug-resistant infection & active against ESBLs producing bacteria (Beta-lactamase/Beta-Lactamase Inhibitor)
COMPOSITION:
Cefepime 1g + Sulbactum 500 mg
MODE OF ACTION:
Cefepime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. Sulbactam is an irreversible ß-lactamase inhibitor that binds the ß-lactamase enzyme and does not allow it to interact with the antibiotic, thus extending its spectrum of activity.
Sulbactam not only potentiates the antibacterial activity by inhibiting beta-lactamases but also forms a protein complex with beta-lactamases. Thus, sulbactam addition extends the spectrum of activity of cefepime.
INDICATIONS
- SSTIs
- Gynecological Infections
- Complicated and Uncomplicated UTI Infections
- Empiric Treatment for fibril neutropenic patient
- Pneumonia
Dosage
Twice or thrice a day in equally divided dosage depending upon disease severity. Maximum daily dose up to 9gm
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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