ENOXAPARIN
Enoxaparin is an anticoagulant that helps to prevent the formation of blood clots. Enoxaparin is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness.
Enoxaparin is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attack.
Enoxaparin was first made in 1981 and approved for medical use in 1993 and is derived from heparin.
Enoxaparin Sodium is the sodium salt of a low molecular weight heparin, obtained by alkaline depolymerisation of the benzyl ester of heparin sodium from porcine intestinal mucosa.
COMPOSITION:
Enaxoparin 60 mg / Enaxoparin 40 mg
MODE OF ACTION:
Enoxaparin is a type of low molecular weight heparin (LMWHs) with a mean molecular weight of 4000 to 5000. It has an immediate onset of action when given in the intravenous form. It binds to and potentiates antithrombin III, a serine protease inhibitor, to form a complex that irreversibly inactivates factor Xa. The mechanism of action of enoxaparin is antithrombin-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, Enoxaparin potentiates preferentially the inhibition of coagulation factors Xa and IIa
INDICATIONS
- Prophylaxis of Deep Vein Thrombosis
- Treatment of Acute DVT
- Prophylaxis of Ischemic Complications of Unstable Angina and Non-Q-wave Myocardial Infarction
- Treatment of Acute ST-segment Elevation MI
Dosage
Treatment of DVT
Adult: 1 mg/kg every 12 hours
Pediatric < 2 months: 1.5 mg/kg sc every 12 hrs
2 months to 17 years: 1 mg/kg sc every 12 hrs
Unstable Angina and Non-Q-wave MI
1 mg/kg every 12 hours
Treatment of Acute STEMI
A single I.V. bolus of 30 mg plus a 1 mg/kg SC dose followed by a 1 mg/kg SC dose every 12 hours
Disclaimer:
This information is for registered medical practitioner only. Anyone other than medical practitioner should consult medical practitioner before using this product.
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